Key result
Elevated hs-cTnT in stable COPD is linked to higher hs-CRP, older age, and increased RVSP.
Why the study?
Information on the association between serum high-sensitivity cardiac troponin T levels and cardiac and pulmonary dysfunction in patients with stable chronic obstructive pulmonary disease is limited.
Cross-Sectional (n=86)
In patients with stable COPD, serum hs-cTnT concentrations are independently associated with systemic inflammation, advancing age, and right cardiac overload.
Should not change troponin use in stable COPD; leaves open whether inflammation or RV pressure drive elevations.
BACKGROUND: High-sensitivity cardiac troponin T (hs-cTnT) in serum is a useful marker of acute myocardial injury, yet information is limited in patients with chronic obstructive pulmonary disease. We aimed to explore the association between hs-cTnT levels and cardiac and pulmonary dysfunction in patients with stable chronic obstructive pulmonary disease and at-risk individuals. METHODS: We examined community-dwelling adults with/without chronic obstructive pulmonary disease, with a life-long smoking history, current symptoms of dyspnea during exertion, prolonged coughing, and/or sputum. Serum hs-cTnT concentrations were measured, and subjects underwent pulmonary function tests, high-resolution computed tomography of the chest, an echocardiogram, and a 6-minute walking test. RESULTS: Eighty-six stable patients were identified (mean age 65.5 years; predicted forced expiratory volume in 1 second [FEV1% predicted] 75.0%). Their overall mean hs-cTnT level was 0.008 ng/mL. Logarithmically transformed hs-cTnT levels significantly and positively correlated with age, smoking index, serum high-sensitivity C-reactive protein levels, right ventricle systolic pressure, low attenuation area percentage, and brain natriuretic peptide levels (range r=0.231-0.534, P=0.000 to P=0.042). Further, logarithmically transformed hs-cTnT values significantly and negatively correlated with forced vital capacity, FEV1% predicted, diffusion capacity, arterial oxygen tension, and 6-minute walking distance (range r= -0.482 to -0.377, P=0.000 to P=0.002). Multivariate analyses showed that hs-cTnT values varied independently according to the following three parameters: high-sensitivity C-reactive protein levels (B=0.157, β=0.450, t=3.571, P=0.001), age (B=0.008, β=0.352, t=2.789, P=0.009), and right ventricular systolic pressure (B=0.008, β=0.280, t=2.202, P=0.035). CONCLUSION: Even in patients with stable chronic obstructive pulmonary disease, the serum troponin T concentration was controlled by at least three major factors, ie, systemic inflammation, advancing age, and right cardiac overload.
No takes yet. Share an insight, caveat, or question.
Kida et al. (2015) conducted a cross-sectional in stable chronic obstructive pulmonary disease (n=86). Serum high-sensitivity cardiac troponin T (hs-cTnT) levels was evaluated on Association between hs-cTnT levels and cardiac and pulmonary dysfunction parameters. In patients with stable COPD, serum hs-cTnT levels were independently associated with hs-CRP (β=0.450, P=0.001), age (β=0.352, P=0.009), and right ventricular systolic pressure (β=0.280, P=0.035).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: