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A one-pot cascade synthesis of pyrazolopyridazine from 4-(bromo(aryl)methyl)-3-chloropyridazines in PEG-400, in an ecofriendly solvent system has been developed. A series of pyrazolopyridazines (2a-i) were synthesized by using bidentate electron-donor ligand in good yield (60-85%). The present cascade protocol included nucleophilic substitution, ring closer and oxidative aromatization in single precedential step.rnrn
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Gayake et al. (2022) studied this question.
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