In vitro study reveals cytotoxic activity of Melodinus morsei monoterpenoid alkaloids against five tumor cell lines, indicating potential antitumor therapeutic relevance.
Three new monoterpenoid alkaloids, melomorines A–C (1–3), along with melohemsine B (4), were isolated from the 70% ethanol extract of the aerial parts of Melodinus morsei. Structural elucidation of all the compounds was performed on the basis of spectral data. All the compounds were tested in vitro for cytotoxic activities. As a result, alkaloids 1, 2, and 4 exhibited cytotoxicities against all the five tested tumor cell lines with IC50 value of less than 20 μM.
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Yin et al. (2017) studied this question.
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