Key result
Fasting over 4 hours is linked to ~33% higher odds of postinduction low BP.
Why the study?
It was hypothesized that prolonged preoperative fasting causes volume depletion manifesting as low blood pressure, prompting an evaluation of fluid fasting duration and postinduction low blood pressure in children.
Does prolonged fluid fasting duration increase the risk of postinduction low blood pressure in anesthetized children undergoing elective surgery?
Cohort (n=15,543)
No
Does prolonged fluid fasting duration increase the risk of postinduction low blood pressure in anesthetized children undergoing elective surgery?
Odds Ratio: 1.33 (95% CI 1.07–1.64)
Absolute Event Rate: 8.1% vs 5.6%
p-value: p=0.009
Longer durations of clear fluid fasting in anesthetized children are associated with an increased risk of postinduction low blood pressure during surgical preparation.
No takes yet. Share an insight, caveat, or question.
Longer fasting was associated with higher postinduction hypotension odds in children; leaves open whether shortening fasting improves outcomes.
Simpao et al. (2020) conducted a cohort in Children undergoing elective surgery (n=15,543). Prolonged fluid fasting duration (4 to 8 hours) vs. Fasting less than 4 hours was evaluated on Low systolic blood pressure during surgical preparation (epoch 2) (adjusted OR 1.33, 95% CI 1.07 to 1.64, p=0.009). Compared with fasting <4 hours, fasting 4 to 8 hours (OR 1.33; 95% CI 1.07-1.64) and >12 hours (OR 1.28; 95% CI 1.04-1.57) were associated with higher odds of postinduction low blood pressure.
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