Key result
Left atrial myxoma linked to severe pancytopenia driven by mechanical blood cell damage.
Why the study?
Left atrial myxoma accompanied by pancytopenia and pathological findings suggestive of pulmonary hypertension is a rare clinical presentation requiring detailed characterization.
Case Report (n=1)
This case report highlights that left atrial myxoma can present with severe pancytopenia due to mechanical destruction of blood cells and can cause pulmonary hypertension mimicking mitral stenosis.
Answers are grounded in this paper and cite their sources.
May prompt myxoma consideration in unexplained adolescent pancytopenia with pulmonary hypertension; hypothesis-generating for mechanical cytopenias.
A case of left atrial myxoma accompanied by peculiar symptoms is reported. A 15-year old boy had progressive congestive heart failure and three episodes of acute attacks of panctyopenia. The anemia was accompanied by helmet-shaped, broken red blood cells, erythroid hyperplasia and elevation of indirect bilirubin. The thrombocytopenia gave rise to hemorrhagic tendency of the skin and mucous membrane. The leukocytopenia was seen at the same time. The patient also had general constitutional disturbances showing generalized malaise, persistent fever, elevation of erythrocyte sedimentation rate, positive C-reactive protein, pulmonary infection and anginal attacks. Postmortem examinations revealed a left atrial myxoma and intricated pulmonary changes. There was obliterative endarteritis of the left coronary branch and pulmonary arteries. The interstitial pulmonary fibrosis was also prominent. The pancytopenia should have been induced by the mechanical damage of circulating blood cells by the left atrial myxoma. The pathological findings of the lungs were highly suggestive of pulmonary hypertension, which was assumed to be due to mitral block caused by the atrial myxoma.
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Kawanishi et al. (1974) conducted a case report in Left atrial myxoma (n=1). Left atrial myxoma was evaluated. A 15-year-old boy with a left atrial myxoma developed severe pancytopenia likely due to mechanical damage of circulating blood cells and pathological findings suggestive of pulmonary hypertension.
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