Key result
Saline batch cooling outperforms closed-loop autologous blood cooling with lower temperatures and greater cooling capacity.
Saline batch cooling provides superior cooling capacity compared to closed-loop autologous blood cooling for localized tissue cooling catheters, though hemodilution risks must be considered.
Saline batch cooling may enhance catheter design for tissue cooling; leaves open clinical translation pending human safety data.
Recent revascularization success for ischemic stroke patients using stentrievers has created a new opportunity for therapeutic hypothermia. By using short term localized tissue cooling interventional catheters can be used to reduce reperfusion injury and improve neurological outcomes. Using experimental testing and a well-established heat exchanger design approach, the ɛ-NTU method, this paper examines the cooling performance of commercially available catheters as function of four practical parameters: (1) infusion flow rate, (2) catheter location in the body, (3) catheter configuration and design, and (4) cooling approach. While saline batch cooling outperformed closed-loop autologous blood cooling at all equivalent flow rates in terms of lower delivered temperatures and cooling capacity, hemodilution, systemic and local, remains a concern. For clinicians and engineers this paper provides insights for the selection, design, and operation of commercially available catheters used for localized tissue cooling.
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Merrill et al. (2016) studied Ischemic stroke. Saline batch cooling vs. Closed-loop autologous blood cooling was evaluated on Cooling performance (delivered temperatures and cooling capacity). Saline batch cooling outperformed closed-loop autologous blood cooling at all equivalent flow rates in terms of lower delivered temperatures and cooling capacity.
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