Effect of Porphyra Extract on Blood Pressure in Spontaneously Hypertensive Rats

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Key Points

To evaluate the antihypertensive effects of fermented Porphyra extract and investigate its potential mechanism in spontaneously hypertensive rats.
Administered a single oral dose of fermented Porphyra extract (2 mg/kg) to spontaneously hypertensive rats (SHR).
Fed SHRs diets supplemented with 0.001% or 0.003% fermented Porphyra extract over 35 days to observe long-term blood pressure changes.
Assayed angiotensin-converting enzyme (ACE) activity in serum, abdominal aorta, and lung tissues after 35 days of feeding.
A single oral dose of 2 mg/kg fermented Porphyra extract induced an acute blood pressure-lowering effect in SHRs.
Dietary intake of 0.001% and 0.003% extract for 35 days suppressed the progressive rise of blood pressure in SHRs.
Long-term administration decreased ACE activity in serum, abdominal aorta, and lungs, indicating that GABA and ACE-inhibiting compounds contribute to blood pressure control.

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Demonstrates blood pressure reduction by fermented Porphyra extract in hypertensive rats, indicating mediation via ACE inhibition.

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Umekawa et al. (2008) studied this question.

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