An increase in the basal metabolic rate is often found in patients with acromegaly when the body size, as measured by height and weight is used as a reference standard (Boothly & Sandford, 1922, Cushing & Davidoff, 1927, Davies, 1941). The possibility exists, however, that this reference standard might introduce systematic errors in measurements of BMR in acromegalic patients. Thus, the kyphosis and kyphoscoliosis frequently present in this disease (Atkinson, 1938) lead to erroneously low values for body height, and the DuBois formula relating body surface area to height and weight may not hold true in the case of acromegaly (Cushing & Davidoff, 1927). Furthermore, the physiological basis of body size as reference standard for BMR, in general, has been critisized, lean body mass or cell mass being considered as preferable in this respect (see Ikkos, 1956).
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Ikkos et al. (1956) studied this question.