Key result
Muscle biopsies identify rare familial myopathy with acid phosphatase-positive crescents in two siblings with cardiomyopathy.
Case Report (n=2)
This report identifies a rare familial myopathy affecting both cardiac and skeletal muscle, characterized by distinctive subsarcolemmal vermiform deposits.
May raise suspicion for rare myopathy in familial cardiomyopathy; leaves open genetic basis and prevalence.
Distinctive subsarcolemmal acid phosphatase-positive crescents were found in many muscle fibers of triceps muscle biopsies from 2 siblings with cardiomyopathy. The crescents appeared as dense osmophilic material in irregular vermiform arrays on electron microscopy. However, both patients had clinically normal skeletal muscle function. These 2 cases are believed to represent a rare familial myopathy affecting cardiac and skeletal muscle.
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Becker et al. (1987) conducted a case report in Familial Cardiomyopathy (n=2). Familial myopathy with subsarcolemmal vermiform deposits was evaluated on Presence of subsarcolemmal acid phosphatase-positive crescents in muscle fibers. Two siblings with cardiomyopathy were found to have distinctive subsarcolemmal acid phosphatase-positive crescents in triceps muscle biopsies, representing a rare familial myopathy.
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