Why the study?
Does L-carnitine and a long-chain fatty-acid-free diet improve cardiac symptoms and echocardiographic findings in patients with familial hypertrophic cardiomyopathy and muscle carnitine deficiency?
Does L-carnitine and a long-chain fatty-acid-free diet improve cardiac symptoms and echocardiographic findings in patients with familial hypertrophic cardiomyopathy and muscle carnitine deficiency?
L-carnitine supplementation and dietary modification may improve cardiac symptoms and echocardiographic findings in patients with familial hypertrophic cardiomyopathy associated with muscle carnitine deficiency.
Hypothesis-generating for L-carnitine and diet in carnitine-deficient hypertrophic cardiomyopathy; controlled trials needed before practice change.
Five members of the same family, along three generations, presented with hypertrophic cardiomyopathy. Neurological examination, muscle strength, electromyography, and serum creatine kinase were normal. Skeletal muscle biopsy showed abnormal lipid accumulation and carnitine deficiency. In three patients the cardiac symptoms and echocardiographic findings improved after treatment with L-carnitine, 3-4 g daily, and a long-chain fatty-acid-free diet.
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Bautista et al. (1990) studied this question.
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