Key result
Serum IGF-1 and IGFBP-3 peak earlier in girls, establishing new reference ranges for Chinese children.
Why the study?
Serum IGF-1 and IGFBP-3 values should be ethnic-specific, but reference ranges for Chinese children aged 6-18 years were not established.
Cross-Sectional (n=837)
Yes
This study established ethnic-specific reference ranges for serum IGF-1 and IGFBP-3 in Chinese children aged 6-18 years to facilitate growth monitoring and clinical diagnosis.
May refine GH assessment in Chinese children using ethnic-specific ranges; leaves open validation in other populations and clinical outcomes.
Serum levels of insulin-like growth factor-1(IGF-1) and insulin-like growth factor binding protein-3(IGFBP-3) reflect endogenous growth hormone secretion, and serum IGF-1 and IGFBP-3 values should be ethnic-specific, thus we established the reference ranges for serum IGF-1 and IGFBP-3 in Chinese children aged 6-18 yr according to age, sex, puberty stage and BMI. The study was included 837 children (age 6-18 yr, 416 boys and 421 girls) from different schools in Daqing, Beijing and Shanghai. Serum IGF-1 and IGFBP-3 were determined by a chemiluminescent assay system (IMMULITE 1000). The results show that IGF1 reached peak levels at around 13 yr in boys and 11 yr in girls while IGFBP-3 peaked at 14 yr in boys, and 11 yr in girls. Both IGF-1 and IGFBP-3 were at platform or decreased slightly after these ages. At each corresponding age, IGF-1 levels tended to be higher in boys compared to girls, while girls had higher IGFBP-3 levels than boys. A model for calculation of standard deviation scores of IGF-1 and IGFBP3 according to age, sex and pubertal stage was established. These normative data should facilitate child care, growth monitoring, clinical diagnosis and to follow up on GH treatment.
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Xu et al. (2010) conducted a cross-sectional in Healthy children and adolescents (n=837). Age, sex, and pubertal stage was evaluated on Peak serum levels and reference ranges of IGF-1 and IGFBP-3. Serum IGF-1 reached peak levels at around 13 years in boys and 11 years in girls, while IGFBP-3 peaked at 14 years in boys and 11 years in girls, establishing age-, sex-, and puberty-specific reference ranges for Chinese children.
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