Answers are grounded in this paper and cite their sources.
CD4SP Treg cell precursors in the thymus and is critical for TCR-dependent IL-2 production, which drive chromatin remodeling at the FoxP3 locus as well as other Treg-effector gene loci in an autocrine/paracrine manner. Together, our results demonstrate a novel role for DNA demethylation in regulating the TCR response and promoting Treg cell differentiation. These findings highlight a novel epigenetic pathway to promote the generation of endogenous Treg cells for mitigation of autoimmune responses.
No takes yet. Share an insight, caveat, or question.
Teghanemt et al. (2023) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: