Key result
Growth hormone receptor activation controls growth and metabolism genes with therapeutic implications for short stature.
Why the study?
Molecular techniques have recently provided a basis for understanding growth hormone receptor activation and its clinical actions, which were previously unclear.
Design
Review article summarizing molecular mechanisms of GH receptor activation
Authors
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Molecular insights into GH receptor signaling extend basic understanding; clinical translation in pediatrics remains unproven.
This review summarizes the molecular mechanisms of growth hormone receptor activation and its clinical implications for disorders of short stature.
Lichanska et al. (2008) conducted a review in disorders of short stature. growth hormone (GH) was evaluated. A review of growth hormone receptor activation highlights its molecular mechanisms in controlling gene expression for growth and metabolism, with therapeutic implications for short stature.
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