Key result
Osteoporosis was an independent risk factor for peripheral artery disease in both men (10.9% vs 3.0% normal BMD; OR 2.3, p<0.001) and women (11.8% vs 3.3% normal BMD; OR 1.8, p<0.001).
Why the study?
The association between bone mineral density scores and the prevalence of peripheral artery disease in a large cohort was investigated to clarify their relationship.
Is abnormal bone mineral density associated with an increased prevalence of peripheral artery disease?
Observational
Is abnormal bone mineral density associated with an increased prevalence of peripheral artery disease?
Odds Ratio: 2.3
Absolute Event Rate: 10.9% vs 3%
p-value: p=<0.001
Abnormal bone mineral density (osteopenia and osteoporosis) is independently associated with a higher prevalence of peripheral artery disease in both men and women.
Low BMD linked to higher PAD prevalence in observational data; hypothesis-generating and should not yet change practice.
The purpose of the current study was to investigate the association between bone mineral density (BMD) scores and the prevalence of peripheral artery disease (PAD) in a large cohort of subjects who underwent arterial Doppler assessments and calcaneal bone densitometry. The study was performed using data obtained from Life Line Screening Inc. Subjects were self-selected and paid for screening tests. The prevalence of PAD was significantly higher in men with osteopenia (4.5%) and osteoporosis (10.9%) compared to men with normal BMD (3.0%) ( p<0.001). Osteopenia (odds ratio (OR) 1.3) and osteoporosis (OR 2.3) were found to be independent risk factors for the presence of PAD in men. The prevalence of PAD was significantly higher in women with osteopenia (4.8%) and osteoporosis (11.8%) compared to women with normal BMD (3.3%) ( p<0.001). Osteopenia (OR 1.15) and osteoporosis (OR 1.8) were found to be independent risk factors for the presence of PAD in women. The current study reports a strong association of abnormal BMD analysis with the prevalence of PAD, which persists even when controlling for age and associated atherosclerotic risk factors. Although the mechanism by which these two disease processes is related is not completely elucidated, the presence of osteoporosis should make clinicians aware of the possibility of occult PAD or associated atherosclerotic disease in appropriate patients.
No takes yet. Share an insight, caveat, or question.
Baldwin et al. (2016) conducted an observational in Peripheral artery disease. Abnormal bone mineral density (osteopenia and osteoporosis) vs. Normal bone mineral density was evaluated on Prevalence of peripheral artery disease (OR 2.3, p=<0.001). Osteoporosis was an independent risk factor for peripheral artery disease in both men (10.9% vs 3.0% normal BMD; OR 2.3, p<0.001) and women (11.8% vs 3.3% normal BMD; OR 1.8, p<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: