What question did this study set out to answer?

To evaluate the association between plasma 8-isoprostane concentrations and home blood pressure classifications in an untreated elderly population.

January 1, 2004Hypertension ResearchOpen Access

Increased Plasma 8-Isoprostane Levels in Hypertensive Subjects: the Tsurugaya Project

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Authors

AHAtsushi HozawaPreventive Cardiology SESatoru EbiharaTohoku University KOKaori OhmoriYamagata University

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Implication

Cross-sectional study finds higher plasma 8-isoprostane concentrations in older adults with severe hypertension, suggesting a link between oxidative stress and elevated blood pressure.

Key Points

To evaluate the association between plasma 8-isoprostane concentrations and home blood pressure classifications in an untreated elderly population.
Assessed 569 participants aged 70 years and older who were not taking antihypertensive medication.
Categorized participants based on home blood pressure: normotensive (<135/85 mmHg), hypertensive (135/85–160/90 mmHg), and severely hypertensive (≥160/90 mmHg).
Adjusted for covariates including age, sex, antioxidant vitamin use, smoking, alcohol consumption, body mass index, NSAIDs, diabetes, hypercholesterolemia, heart rate, and serum creatinine.
Mean plasma 8-isoprostane was significantly higher in the severely hypertensive group (21.1 ± 5.2 pg/ml) compared with the normotensive (20.2 ± 4.9 pg/ml) and hypertensive (19.7 ± 5.1 pg/ml) groups.
The elevated 8-isoprostane level in severely hypertensive participants remained statistically significant after adjusting for all measured demographic, lifestyle, and clinical confounders.

Cite This Study

Hozawa et al. (2004) studied this question.

synapsesocial.com/papers/6aa8e0674534d1324570eddc https://doi.org/10.1291/hypres.27.557

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Implication

Cross-sectional study finds higher plasma 8-isoprostane concentrations in older adults with severe hypertension, suggesting a link between oxidative stress and elevated blood pressure.

Increased Plasma 8-Isoprostane Levels in Hypertensive Subjects: the Tsurugaya Project

Discussion

Member takes

Implication

Key Points

Cite This Study

Increased Plasma 8-Isoprostane Levels in Hypertensive Subjects: the Tsurugaya Project

Discussion

Member takes

Implication

Key Points

Cite This Study

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