Key result
Low preoperative prognostic nutritional index is linked to ~65% greater risk of postoperative AKI.
Why the study?
This study aimed to assess the clinical association of the preoperative prognostic nutritional index with the risk of postoperative acute kidney injury.
Does a low preoperative prognostic nutritional index increase the risk of postoperative acute kidney injury?
Meta-Analysis (n=9,185)
Does a low preoperative prognostic nutritional index increase the risk of postoperative acute kidney injury?
Odds Ratio: 1.65
p-value: p=0.001
A low preoperative prognostic nutritional index is associated with increased risks of postoperative acute kidney injury, infection, and mortality, suggesting its potential utility for preoperative risk stratification.
May inform preoperative risk stratification; hypothesis-generating and requires prospective validation before clinical adoption.
This meta-analysis aimed to assess the clinical association of the preoperative prognostic nutritional index (pre-PNI) with the risk of postoperative acute kidney injury. Four databases (e.g., Medline) were searched from inception to December 2022 to investigate the association between pre-PNI (i.e., low vs. high) and PO-PNI as well as the correlation between pre-PNI and other postoperative prognostic indices. Overall, 13 observational studies, including 9185 patients, were eligible for analysis. A low PNI was related to increased risks of PO-AKI [odd ratio (OR) = 1.65, p = 0.001, 3811 patients], postoperative infection (OR = 2.1, p < 0.00001, 2291 patients), and mortality (OR = 1.93, p < 0.0001, 2159 patients). Albeit statistically nonsignificant, a trend was noted, linking a low PNI to higher risks of postoperative bleeding (OR = 2.5, p = 0.12, 1157 patients) and stroke (OR = 1.62, p = 0.07, 2036 patients). Pooled results revealed a prolonged intensive care unit (ICU) stay in patients with low PNIs compared to those with high PNIs (MD: 0.98 days, p = 0.02, 2209 patients) without a difference in hospital stay between the two groups (MD: 1.58 days, p = 0.35, 2249 patients). This meta-analysis demonstrated an inverse correlation between PNI and the risks of PO-AKI, postoperative infection, and mortality, as well as the length of ICU stay, which warrants further investigations for verification.
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Liu et al. (2023) conducted a meta-analysis in Postoperative acute kidney injury (n=9,185). Low preoperative prognostic nutritional index (pre-PNI) vs. High pre-PNI was evaluated on Postoperative acute kidney injury (PO-AKI) (OR 1.65, p=0.001). A low preoperative prognostic nutritional index was associated with an increased risk of postoperative acute kidney injury (OR 1.65; p=0.001).
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