Key result
Uncorrected congenital heart defects linked to a ~5-fold higher prevalence of coagulation abnormalities vs controls.
Why the study?
Coagulation abnormality is a significant complication and cause of mortality in children with uncorrected congenital heart defects, but the prevalence and associated factors required determination.
Do children with uncorrected congenital heart defects have a higher prevalence of coagulation abnormalities compared to healthy controls?
Cross-Sectional (n=140)
No
Do children with uncorrected congenital heart defects have a higher prevalence of coagulation abnormalities compared to healthy controls?
Children with uncorrected congenital heart defects, particularly those with cyanotic CHD, have a significantly higher prevalence of coagulation abnormalities compared to healthy controls, highlighting the need for routine screening.
Potential hemostatic risks in uncorrected pediatric CHD merit attention; leaves open whether screening improves outcomes.
Background Coagulation abnormality is a significant complication and cause of mortality in children with uncorrected congenital heart defects (CHD). The aim of this study was to determine the prevalence of coagulation abnormalities and the associated factors in children with uncorrected CHD. Method A cross sectional study conducted to determine the prevalence of coagulation abnormalities among 70 children with uncorrected CHD aged six months to 17 years and 70 age and sex matched apparently healthy controls. Coagulation abnormality was determined using complete blood count, prothrombin time, activated partial thromboplastin time and D-dimer assay. Results The prevalence of coagulation abnormalities among children with CHD and controls was 37.1% and 7.1% respectively. Children with Cyanotic CHD had a significantly higher prevalence of coagulation abnormalities compared to children with Acyanotic CHD (57.1% versus 17.1%). Haematocrit and oxygen saturation levels were significantly associated with coagulation abnormalities. Conclusion This study affirms that coagulation abnormality is high in children with uncorrected CHD. Oxygen saturation and haematocrit are factors of coagulation abnormalities. Routine coagulation screening is recommended especially in children with cyanotic congenital heart defects to improve their quality of life and reduce morbidity and mortality while awaiting definitive surgeries.
No takes yet. Share an insight, caveat, or question.
Majiyagbe et al. (2022) conducted a cross-sectional in Uncorrected congenital heart defects (n=140). Uncorrected congenital heart defects vs. Healthy age and sex matched controls was evaluated on Prevalence of coagulation abnormalities. Uncorrected congenital heart defects were associated with a higher prevalence of coagulation abnormalities compared to healthy controls (37.1% vs 7.1%).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: