Key result
Sufficient physical activity is linked to ~27% lower mortality in early stage CKD.
Why the study?
Although a healthy lifestyle lowers CKD and mortality risk in the general population, definitive evidence regarding the benefits of physical activity and other health-related behaviors in early-stage CKD is lacking.
Do health-related behaviors such as physical activity and smoking cessation reduce the risk of ESRD and mortality in patients with early-stage CKD?
Cohort (n=83,470)
Yes
Do health-related behaviors such as physical activity and smoking cessation reduce the risk of ESRD and mortality in patients with early-stage CKD?
Hazard Ratio: 0.73 (95% CI 0.64–0.83)
p-value: p=<0.001
Sufficient physical activity and smoking cessation are associated with significantly lower risks of mortality and ESRD progression in patients with early-stage CKD.
May support lifestyle counseling in early CKD; hypothesis-generating and requires interventional trials before changing practice.
A healthy life style is associated with decreased risk of chronic kidney disease (CKD) and mortality in the general population. However, there is no definitive evidence of the benefits of physical activity and other health-related behaviors in the early-stage of CKD. This study aimed to explore the association between health-related behaviors and end-stage renal disease (ESRD) and mortality in the early stages of CKD. The National Health Insurance Service (NHIS) database from 1 January 2009 to 31 December 2016 was used to screen 83,470 subjects with early stage CKD. Cox proportional hazard regression analysis was used to evaluate the association between health-related behaviors and ESRD and death. Kaplan–Meier curves for mortality and ESRD were plotted according to the physical activity, smoking status, and alcohol consumption pattern. Risk of death decreased significantly in subjects who engaged in sufficient physical activity (adjusted Hazard Ratio (HR) 0.73; 95% CI: 0.64–0.83; p < 0.001). Risk of ESRD and death increased significantly in the current smoker with adjusted HR of 1.44 (95% CI: 1.06–1.95; p < 0.02) and 1.61 (95% CI: 1.44–1.80; p < 0.001) respectively. Therefore, systematic interventions to encourage physical activity and smoking cessation need to be actively considered in the early stages of CKD.
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Lee et al. (2019) conducted a cohort in Early stage chronic kidney disease (n=83,470). Sufficient physical activity vs. Insufficient physical activity was evaluated on Death (HR 0.73, 95% CI 0.64-0.83, p=<0.001). Sufficient physical activity was associated with a decreased risk of death (HR 0.73; 95% CI 0.64-0.83; p<0.001) in subjects with early stage chronic kidney disease.
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