All articles of this category The total synthesis of prostaglandin F 2α (PGF 2α ) was accomplished via nickel-promoted cyclization of 1,3-diene and aldehyde in a chain in the presence of 1,3-cyclohexadiene (1,3-CHD). The cyclization of 16 prepared in an optically active form from chiral epoxy alcohol 10 stereoselectively gave the key intermediate 18 , which has both an α-chain and the four contiguous chiral carbon centers in PGF 2α , in a one-pot reaction. Intermediate 18 was successfully transformed into PGF 2α . prostaglandin - F 2α - nickel - cyclization - 1,3-diene - aldehyde
No takes yet. Share an insight, caveat, or question.
Sato et al. (1997) studied this question.