Why the study?
Does nifedipine and oxygen administration reduce pulmonary artery pressure and total pulmonary resistance in a patient with severe pulmonary hypertension secondary to CREST syndrome?
Case Report (n=1)
Does nifedipine and oxygen administration reduce pulmonary artery pressure and total pulmonary resistance in a patient with severe pulmonary hypertension secondary to CREST syndrome?
Nifedipine and oxygen administration may provide reversible reduction of pulmonary hypertension in patients with the CREST syndrome variant of scleroderma.
Answers are grounded in this paper and cite their sources.
May support reversible PH reduction with nifedipine-oxygen in CREST syndrome; hypothesis-generating, requires prospective confirmation.
A patient with severe pulmonary hypertension secondary to the CREST syndrome variant of scleroderma is described. Acute reductions in both pulmonary artery pressure and total pulmonary resistance were seen with nifedipine and oxygen administration. Reductions in resistance were maintained for over one month with this combination. These results raise the possibility that some of the pulmonary hypertension seen in this condition is reversible.
No takes yet. Share an insight, caveat, or question.
Morrison et al. (1984) conducted a case report in Severe pulmonary hypertension secondary to the CREST syndrome variant of scleroderma (n=1). Nifedipine and oxygen administration was evaluated on Pulmonary artery pressure and total pulmonary resistance.
Synapse has enriched 10 related papers. Consider them for comparative context: