August 1, 2002The American Journal of Surgical Pathology
Primary Sarcomas of the Brain and Spinal Cord
Key result
High-grade primary CNS sarcomas linked to ~66% lower five-year survival versus low-grade tumors.
- P=0.03
- n=18
Why the study?
Primary sarcomas of the central nervous system are exceedingly rare and their clinicopathologic features require further characterization.
Population
18 patients with primary central nervous system sarcomas, median age 28 years
Comparison
Subtotal to gross total tumor resection with or without radiotherapy and/or chemotherapy
Design
Observational case series
Follow-up
Median 2.3 years
Authors
Discussion
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Member takes
Implication
Grading may inform prognosis in rare CNS sarcomas; hypothesis-generating and requires validation before guiding care.
Study Design
Type
Observational (n=18)
Structured PICO
P
Population
18 patients with primary central nervous system sarcomas diagnosed between 1959 and 1999, followed for a median of 2.3 years.
E
Exposure
Subtotal to gross total tumor resection (16 also received radiotherapy and/or chemotherapy)
O
Outcome
Survival at 5 yearshard clinical
Main Result
Absolute Event Rate: 28% vs 83%
p-value: p=0.03
Primary central nervous system sarcomas are rare tumors that most often affect young and middle-aged adults, with high-grade tumors having a 5-year survival of 28%.
Cite This Study
Oliveira et al. (2002) conducted an observational in Primary central nervous system sarcomas (n=18). High-grade tumors vs. Low-grade tumors was evaluated on Survival at 5 years (p=0.03). High-grade primary central nervous system sarcomas were associated with significantly lower 5-year survival compared to low-grade neoplasms (28% vs 83%, p=0.03).