What question did this study set out to answer?

To investigate the physiological mechanism by which the PPAR-gamma2 Pro12Ala polymorphism enhances insulin sensitivity by assessing insulin-mediated suppression of lipolysis in humans.

April 1, 2001DiabetesOpen Access

Pro12Ala Polymorphism in the Peroxisome Proliferator–Activated Receptor-γ2 Gene Is Associated With Increased Antilipolytic Insulin Sensitivity

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To investigate the physiological mechanism by which the PPAR-gamma2 Pro12Ala polymorphism enhances insulin sensitivity by assessing insulin-mediated suppression of lipolysis in humans.
Evaluated 68 lean individuals (BMI <27.0 kg/m2) matched for age, BMI, waist-to-hip ratio, and sex, comparing 51 non-carriers (Pro/Pro) with 17 carriers of the polymorphism (X/Ala).
Measured lipolysis using a d5-glycerol isotope infusion to track the glycerol rate of appearance, determining the half-maximal insulin suppression concentration (EC50) via three-step (n=21) or standard (n=47) hyperinsulinemic-euglycemic clamps.
Insulin sensitivity index (ISI) of glucose disposal was higher in the X/Ala group at 0.129±0.008 vs. 0.095±0.006 µmol·kg⁻¹·min⁻¹·pmol⁻¹·l⁻¹ in controls (P=0.003).
The insulin concentration required for half-maximal lipolysis suppression (EC50) was lower in X/Ala carriers compared to controls (44±3 vs. 56±2 pmol/l; P=0.001).
EC50 of lipolysis was significantly correlated with the insulin sensitivity index of glucose disposal (r=0.42, P=0.002).

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Implication

Observational study reveals increased antilipolytic and glucose disposal insulin sensitivity in lean PPAR-gamma2 Ala carriers, suggesting adipose-mediated metabolic protection.

Cite This Study

Stümvoll et al. (2001) studied this question.

synapsesocial.com/papers/6aa8e7e32ed5bb30c9299999 https://doi.org/10.2337/diabetes.50.4.876

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Implication

Observational study reveals increased antilipolytic and glucose disposal insulin sensitivity in lean PPAR-gamma2 Ala carriers, suggesting adipose-mediated metabolic protection.

Pro12Ala Polymorphism in the Peroxisome Proliferator–Activated Receptor-γ2 Gene Is Associated With Increased Antilipolytic Insulin Sensitivity

Key Points

Discussion

Implication

Cite This Study

Pro12Ala Polymorphism in the Peroxisome Proliferator–Activated Receptor-γ2 Gene Is Associated With Increased Antilipolytic Insulin Sensitivity

Key Points

Discussion

Implication

Cite This Study

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