Key result
NAFLD in T2D linked to a ~60% higher rate of LV diastolic dysfunction.
Why the study?
Growing evidence links NAFLD with left ventricular diastolic dysfunction, but the independent correlation between LV diastolic dysfunction and hepatic steatosis and fibrosis in T2DM required further investigation.
Is nonalcoholic fatty liver disease associated with increased left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus?
Case-Control (n=100)
Is nonalcoholic fatty liver disease associated with increased left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus?
Absolute Event Rate: 64% vs 40%
p-value: p=0.011
Nonalcoholic fatty liver disease is significantly associated with early left ventricular diastolic dysfunction in patients with type 2 diabetes.
Supports diastolic function evaluation in T2DM with NAFLD; hypothesis-generating and should not yet change practice.
Objectives: To determine if the poor diastolic function of the left ventricle was independently correlated with hepatic steatosis and fibrosis in type 2 diabetes mellitus (T2DM). Background: There is growing evidence that it is related to nonalcoholic fatty liver disease (NAFLD) and left ventricular diastolic dysfunction (LVDD). We sought to learn more about the relationship between LV diastolic dysfunction and liver fibrosis in T2DM patients. Methods: a case control study was conducted on 100 patients, 50 of them with type 2 diabetes patients without NAFLD and 50 diabetic patients with NAFLD. NAFLD fibrosis score (NFS) and abdominal ultrasonography were used to determine the presence of NAFLD. In order to detect the presence of left ventricular diastolic dysfunction and determine the ratio of early to late ventricular filling (E/A) and the deceleration time, pulsed-wave Doppler echocardiography was performed. Results: Compared to the non-NAFLD group, the NAFLD group had significantly more left ventricular diastolic dysfunction (64% vs. 40%,) with P=0.011. Conclusions: Non-alcoholic steatosis is associated with early diastolic dysfunction echocardiographic characteristics seen in diabetic patients.
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Dawood et al. (2024) conducted a case-control in Type 2 diabetes mellitus (n=100). Non-alcoholic fatty liver disease (NAFLD) vs. No NAFLD was evaluated on Left ventricular diastolic dysfunction (p=0.011). In type 2 diabetic patients, NAFLD was associated with a significantly higher rate of left ventricular diastolic dysfunction compared to those without NAFLD (64% vs. 40%, P=0.011).
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