Key result
Nonalcoholic fatty liver disease in patients with type 2 diabetes was associated with higher left atrial volume, left ventricular volume index, and left ventricle filling pressure index (P < 0.05).
Why the study?
LVDD is the first preclinical sign of diabetic cardiomyopathy, and NAFLD increases cardiovascular risk in T2DM, but their association required evaluation.
Is nonalcoholic fatty liver disease associated with early left ventricular diastolic dysfunction in patients with type 2 diabetes?
Population
40 patients with T2DM
Comparison
20 patients with NAFLD vs 20 without NAFLD
Authors
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Supports NAFLD-LVDD association in T2DM; hypothesis-generating and requires larger prospective confirmation before practice implications.
Case-Control (n=40)
Is nonalcoholic fatty liver disease associated with early left ventricular diastolic dysfunction in patients with type 2 diabetes?
p-value: p=<0.05
In patients with type 2 diabetes, the presence of NAFLD is independently associated with early left ventricular diastolic dysfunction, highlighting a potential link to diabetic cardiomyopathy.
Sheba et al. (2022) conducted a case-control in Type 2 diabetes mellitus (n=40). Nonalcoholic fatty liver disease (NAFLD) vs. Without NAFLD was evaluated on Left atrial volume, left ventricular volume index, and left ventricle filling pressure index (E/é) (p=<0.05). Nonalcoholic fatty liver disease in patients with type 2 diabetes was associated with higher left atrial volume, left ventricular volume index, and left ventricle filling pressure index (P < 0.05).
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