Animal study reveals that long polar fimbriae mutations decrease intestinal colonization and tissue lesions in sheep and pigs, indicating a key role in bacterial adherence.
The contribution of long polar fimbriae to intestinal colonization by Escherichia coli O157:H7 was evaluated in sheep, conventional pigs, and gnotobiotic piglets. E. coli O157:H7 strains with lpfA1 and lpfA2 mutated were recovered in significantly lower numbers and caused fewer attachment and effacement lesions than the parent strain.
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Jordan et al. (2004) studied this question.
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