What does this research mean for the field?

In patients with type 2 diabetes, supplementation with plant-derived perilla oil significantly reduces fasting blood glucose, whereas marine-derived fish oil significantly reduces serum triglyceride levels. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 10, 2022Lipids in Health and DiseaseOpen Access

Effects of marine-derived and plant-derived omega-3 polyunsaturated fatty acids on erythrocyte fatty acid composition in type 2 diabetic patients

Q: What are the key findings of this study?

In patients with type 2 diabetes, supplementation with perilla oil significantly decreased fasting blood glucose, while fish oil supplementation significantly decreased triglyceride levels.

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Type 2 Diabetes Mellitus and Dyslipidemia (n=180). Intervention: Perilla oil (plant-derived n-3 PUFA) vs. Fish oil (marine-derived n-3 PUFA) or mixed linseed and fish oil. Primary outcome: Fasting blood glucose (FBG) (p=<0.001).

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Key result

Perilla oil lowers fasting blood glucose while fish oil reduces triglycerides in patients with T2D.

P<0.001
n=180

Why the study?

Dietary fatty acid intake alters erythrocyte fatty acid composition, which correlates with glycolipid metabolism disorders, but the differential effects of marine-derived versus plant-derived n-3 PUFAs in T2DM were unclear.

Do marine-derived and plant-derived omega-3 PUFAs have different effects on erythrocyte fatty acid composition and glycolipid metabolism in patients with type 2 diabetes mellitus?

Population

180 T2DM patients

Comparison

Fish oil vs perilla oil vs mixed linseed and fish oil (all 3 g/day)

Design

Randomized double-blinded trial

Follow-up

Six months

Authors

HLHechun LiuJiujiang First People's Hospital FWFeng Wang XLXiaosong LiuFirst People's Hospital of Foshan

Discussion

Member takes

Implication

Perilla oil may aid glycemic control and fish oil triglycerides in type 2 diabetes; extends evidence for source-specific omega-3 effects.

Study Design

Type

RCT (n=180)

Blinding

Double-blind

Randomization

Computer-generated random number list

Multicenter

Structured PICO

Do marine-derived and plant-derived omega-3 PUFAs have different effects on erythrocyte fatty acid composition and glycolipid metabolism in patients with type 2 diabetes mellitus?

Population

180 adults aged 18-70 years with type 2 diabetes and dyslipidemia were randomized to receive fish oil, perilla oil, or a mixture for 6 months.

Intervention

Fish oil 3 g/day (containing EPA and DHA), perilla oil 3 g/day (containing ALA), or mixed linseed and fish oil 3 g/day (containing EPA, DHA and ALA) for 6 months

Comparator

The three intervention groups (fish oil, perilla oil, mixed linseed and fish oil) were compared against each other

Outcome

Erythrocyte fatty acid composition and glycolipid metabolism indexes (fasting blood glucose, insulin, HOMA-IR, C-peptide, total cholesterol, and triglycerides) at 6 monthssurrogate

Main Result

Absolute Event Rate: 7.76% vs 8.19%

p-value: p=<0.001

Plant-derived omega-3 PUFAs (perilla oil) may preferentially improve glucose metabolism, whereas marine-derived omega-3 PUFAs (fish oil) preferentially lower triglycerides in patients with type 2 diabetes.

Limitations

High rate of loss to follow-up (16.7%)
Assessors and analysts were not fully blinded
Most participants were overweight with higher blood pressure, limiting generalizability to normal-weight patients
Fatty acid composition changes during the intervention could not be determined due to end-point measurement only
Lack of a common edible oil (e.g., corn oil) as a true placebo control
Concurrent use of oral hypoglycemic agents or insulin by most participants
Small sample size prevented reliable subgroup analyses

Cite This Study

Liu et al. (2022) conducted an RCT in Type 2 Diabetes Mellitus and Dyslipidemia (n=180). Perilla oil (plant-derived n-3 PUFA) vs. Fish oil (marine-derived n-3 PUFA) or mixed linseed and fish oil was evaluated on Fasting blood glucose (FBG) (p=<0.001). In patients with type 2 diabetes, supplementation with perilla oil significantly decreased fasting blood glucose, while fish oil supplementation significantly decreased triglyceride levels.

synapsesocial.com/papers/6aa8eb6c4534d1324570efb0 https://doi.org/10.1186/s12944-022-01630-0

Topics

Lipid management

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Effects of marine-derived and plant-derived omega-3 polyunsaturated fatty acids on erythrocyte fatty acid composition in type 2 diabetic patients

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Topics

Effects of marine-derived and plant-derived omega-3 polyunsaturated fatty acids on erythrocyte fatty acid composition in type 2 diabetic patients

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Topics

Also Consider