Key result
Advanced NAFLD is linked to ~1800 differentially expressed genes versus mild NAFLD, highlighting mitochondrial and fibrotic networks.
Why the study?
NAFLD progression involves interactions among numerous genes, but core gene networks and key genes associated with progression remain to be identified.
Observational (n=60)
p-value: p=<0.05
RNA sequencing identifies core gene networks and hub genes associated with NAFLD progression, highlighting mitochondrial dysfunction, fibrosis, and epigenetic tumorigenic potential.
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Hypothesis-generating for NAFLD progression biomarkers; leaves open causal roles and therapeutic targeting pending longitudinal validation.
Hotta et al. (2017) conducted an observational in Non-alcoholic fatty liver disease (NAFLD) (n=60). Advanced NAFLD vs. Mild NAFLD was evaluated on Differentially expressed genes (p=<0.05). Advanced NAFLD was associated with 1777 differentially expressed genes (q<0.05) compared to mild NAFLD, highlighting core networks involved in mitochondrial dysfunction, fibrosis, and tumorigenesis.
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