Why the study?
The in vivo role of brown adipocyte-enriched miR-203 in adipose tissue metabolic homeostasis, subcutaneous white adipose tissue browning, and energy homeostasis had not been determined.
Population
Cold-exposed, high-fat diet-fed, ob/ob, db/db, and C57 mice
Comparison
miR-203 knockdown or overexpression vs controls
Design
In vivo and in vitro preclinical animal study
Key result
Overexpression of miR-203 promoted white adipose tissue browning and improved glucose tolerance in high fat diet-fed mice by repressing the IFN-γ signaling pathway.
Authors
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MiR-203 overexpression enhances WAT browning and glucose tolerance in mice; leaves open therapeutic translation to human obesity or cardiometabolic disease.
In vivo mouse models demonstrate that miR-203 promotes white adipose tissue browning and improves glucose tolerance by repressing the IFN-γ signaling pathway.
Guo et al. (2019) studied Obesity and metabolic homeostasis. miR-203 knockdown or overexpression vs. Control was evaluated on Subcutaneous white adipose tissue browning and glucose tolerance. Overexpression of miR-203 promoted white adipose tissue browning and improved glucose tolerance in high fat diet-fed mice by repressing the IFN-γ signaling pathway.
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