Key result
Total red ginseng ginsenosides lower triglycerides ~42% and ameliorate hepatic steatosis in diabetic rats.
Why the study?
This study aims to clarify the material basis of total ginsenosides of red ginseng (RGW) and verify its activity in treating lipid metabolism disorders caused by T2DM.
Does red ginseng (RGW) improve lipid metabolism in preclinical models of Type 2 Diabetes Mellitus?
Does red ginseng (RGW) improve lipid metabolism in preclinical models of Type 2 Diabetes Mellitus?
Answers are grounded in this paper and cite their sources.
Red ginseng extract attenuates lipid deposition in vitro and alters short-chain fatty acid profiles in vivo, suggesting potential benefits for lipid metabolism in Type 2 Diabetes Mellitus.
Objectives: C.A. Meyer, which is one of the widely used medicinal and edible herbs for the treatment of type 2 diabetes mellitus (T2DM). Ginsenosides are its main pharmacologically active ingredient. This study aims to clarify the material basis of total ginsenosides of red ginseng (RGW) and verify the activity of RGW in treating lipid metabolism disorders caused by T2DM. Methods: activity of RGW was verified by fatty degenerated HepG2 cells. Results: experiments by RGW treatment also significantly attenuated lipid deposition in HepG2 cells. RGW upregulated the content of 5 short-chain fatty acids in rat stools, which are related to lipid oxidation and liver gluconeogenesis. Conclusion: The total RGW were quantitatively analyzed by UHPLC-MS, and its effect on lipid metabolism of T2DM was studied. The experiment demonstrated that red ginseng can regulate lipid metabolism and improve lipid deposition, which provides a promising development for red ginseng as a functional food.
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Huang et al. (2022) studied Type 2 Diabetes Mellitus (n=60). Total ginsenosides of red ginseng (RGW) vs. Distilled water (DM control) was evaluated on Serum triglyceride (TG) levels (mmol/ml) (p=<0.05). Total ginsenosides of red ginseng significantly reduced fasting blood glucose, triglycerides, and total cholesterol levels, and ameliorated hepatic steatosis in a rat model of type 2 diabetes mellitus.
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