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April 27, 2022Frontiers in NutritionOpen Access

Studies on Bioactive Components of Red Ginseng by UHPLC-MS and Its Effect on Lipid Metabolism of Type 2 Diabetes Mellitus

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Key result

Total red ginseng ginsenosides lower triglycerides ~42% and ameliorate hepatic steatosis in diabetic rats.

  • P<0.05
  • n=60

Why the study?

This study aims to clarify the material basis of total ginsenosides of red ginseng (RGW) and verify its activity in treating lipid metabolism disorders caused by T2DM.

Does red ginseng (RGW) improve lipid metabolism in preclinical models of Type 2 Diabetes Mellitus?

Population

Fatty degenerated HepG2 cells and rats

Comparison

RGW treatment vs not specified

Design

Preclinical laboratory study

Authors

RHRensong HuangMZMeng ZhangYTYu Tong

Discussion

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Overview

RGW activity in cell models warrants no clinical use yet; leaves open translation to T2DM patients pending rigorous trials.

Structured PICO

Does red ginseng (RGW) improve lipid metabolism in preclinical models of Type 2 Diabetes Mellitus?

P
Population
60 adult male Wistar rats with high-fat diet and STZ-induced type 2 diabetes mellitus, treated for 21 days.
I
Intervention
Total ginsenosides of red ginseng (RGW)
O
Outcome
Lipid deposition in HepG2 cells and content of short-chain fatty acids in rat stoolssurrogate

Main Result

Absolute Event Rate: 1.64% vs 2.83%

p-value: p=<0.05

Red ginseng extract attenuates lipid deposition in vitro and alters short-chain fatty acid profiles in vivo, suggesting potential benefits for lipid metabolism in Type 2 Diabetes Mellitus.

Cite This Study

Huang et al. (2022) studied Type 2 Diabetes Mellitus (n=60). Total ginsenosides of red ginseng (RGW) vs. Distilled water (DM control) was evaluated on Serum triglyceride (TG) levels (mmol/ml) (p=<0.05). Total ginsenosides of red ginseng significantly reduced fasting blood glucose, triglycerides, and total cholesterol levels, and ameliorated hepatic steatosis in a rat model of type 2 diabetes mellitus.

synapsesocial.com/papers/6aa8ee7b16a2a0577c6bfc28https://doi.org/10.3389/fnut.2022.865070
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Also Consider

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