Key result
Aspirin versus placebo yields no reported quantitative results for high-risk preterm preeclampsia.
RCT
May not support aspirin after 16 weeks for preeclampsia prevention; leaves open optimal timing and risk stratification.
(N Engl J Med. 2017;377(7):613–622) Professional associations recommend the prophylactic use of low-dose aspirin (60 to 80 mg d) in pregnant women who are considered to be at high risk for preeclampsia. However, some studies suggest that aspirin started after 16 weeks of gestation does not have a significant benefit, and there remain major challenges in identifying women at high risk for this condition.
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Rolnik et al. (2018) conducted an RCT in Pregnancies at high risk for preterm preeclampsia. Aspirin vs. Placebo was evaluated. The provided abstract does not report any quantitative results for aspirin versus placebo in pregnancies at high risk for preterm preeclampsia.
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