Real-life management of stage III non-small cell lung cancer patients in Italy: the BE-PACIFIC observational study

Paolo Bironzo; Alessandro Morabito; Sonia Silipigni; Vincenzo Adamo; Enrica Capelletto; Sabrina Rossi; Marcello Tiseo; Michele Montrone; Ivan Facilissimo; Gianpiero Romano; Luna Chiara Masini; Giovanni Luca Ceresoli; Cesare Gridelli; Antonio Lugini; Sara Pilotto; Pierosandro Tagliaferri; Emilio Bria; D. Cortinovis; Erika Rijavec; Paolo Borghetti; Matteo Brighenti; Anna Maria Carta; Libero Ciuffreda; Raffaele Giusti; Marianna Macerelli; Francesco Verderame; Francesca Zanelli; Rossana Berardi; Vanesa Gregorc; Concetta Sergi; Emanuela Vattemi; Roberto Ferrara; Pier Luigi Piovano; Lorenzo Livi; Gloria Borra; Stefania Gori; Michele Aieta; Alessandro Bertolini; Fabiana Letizia Cecere; Giulia Pasello; Danilo Rocco; Giuseppe Lo Certo; Livia Marrone; Lucia Simoni; Barbara Roncari; Silvia Novello; S. Ramella; Rossana Critelli; Elisa Cibrario Rocchietti; Simona Carnio; Francesco Passiglia; Valentina Bertaglia; Emanuela Olmetto; Carlo Greco; Edy Ippolito; Barbara Papi; P. Falco; Alessandra Ferro; Alessandro Dal Maso; Giulia Doria; Stefano Frega; Annalisa Nardone; Patrizia Petrillo; Gianluca Cuomo; Maria Bonomi; Valeria Nava; Marta Magni; Serena Verna; Claudia Proto; Rosa Maria Di Mauro; Giulia Galli; Giuseppe Lo Russo; Clara Fugazza; Maria Grazia Viganò; Chiara Lazzari; Paolo Maione; Maria Luisa Barzelloni; Angelo Cirocco; Fiorella Lombardo; Lorenzo Belluomini; Jessica Insolda; Alessandra Marabese; Roberta Camisa; Alessandro Leonetti; Sebastiano Buti; Simona Damiano; Giuliano Palumbo; Alfredo Tartarone; Vittoria Lapadula; Emanuela Zifarone; Stefania Crivellari; Silvia Zai; Fabio Giacchero; C. Bonfadini; Agostino Ponzetti; E. Milanesi; Tiziana Scirelli; Silvana Leo; V. Saracino; Amelia Vantaggiato

doi:10.1016/j.ctarc.2026.101143

January 1, 2026Cancer Treatment and Research CommunicationsOpen Access

Real-life management of stage III non-small cell lung cancer patients in Italy: the BE-PACIFIC observational study

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Key Points

The BE-PACIFIC study aimed to describe real-world diagnostic timelines, treatment patterns, and survival outcomes in stage III non-small cell lung cancer managed according to Italian clinical practice.
Multicentre retrospective and prospective observational cohort study conducted across 40 sites in Italy.
Included adult patients with confirmed stage III non-small cell lung cancer, followed for 12 months after diagnosis using primary and secondary data collection.
The median duration of the diagnostic process was 30.4 days (interquartile range 21.0–60.9 days), and multidisciplinary teams guided treatment plans in 88.7% (260/293) of patients.
Tumour resection was performed in 20.3% of patients (n=60), primarily combined with neoadjuvant (43.3%, n=26) or adjuvant (36.7%, n=22) therapy alone.
Among 236 non-resected patients, 69.9% (n=165) received chemoradiation, followed by consolidation durvalumab in 48.5% (n=80) of those cases.

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Implication

Observational cohort study reports real-world multimodal treatment patterns in stage III non-small cell lung cancer, highlighting high multidisciplinary engagement and consolidation durvalumab uptake.

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Bironzo et al. (2026) studied this question.

synapsesocial.com/papers/6aa8f19a25280296cf299da2 https://doi.org/10.1016/j.ctarc.2026.101143

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Real-life management of stage III non-small cell lung cancer patients in Italy: the BE-PACIFIC observational study

Key Points

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Implication

Discussion

Cite This Study

Real-life management of stage III non-small cell lung cancer patients in Italy: the BE-PACIFIC observational study

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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