Why the study?
Measurement of N-terminal pro-B-type natriuretic peptide is a useful rule-out test for cardiac dysfunction in ICU patients but its role in routine clinical practice versus research is unclear.
Does measurement of N-terminal pro-B-type natriuretic peptide improve diagnostic assessment of cardiac dysfunction in intensive care unit patients?
Does measurement of N-terminal pro-B-type natriuretic peptide improve diagnostic assessment of cardiac dysfunction in intensive care unit patients?
Effect estimate: AUC 0.76 (95% CI 0.69 to 0.83)
NT-proBNP measurement serves as a valuable adjunctive rule-out test for cardiac dysfunction in the intensive care setting.
Measurement of N-terminal pro-B-type natriuretic peptide has been shown a good rule-out test for cardiac dysfunction in patients in the intensive care unit. The peptide measurement should not be used as a replacement for other forms of monitoring, and performs best as a diagnostic test when interpreted together with other clinical findings and investigations. At a cutoff value similar to that found in other clinical studies in acute decompensated heart failure, measurement of N-terminal pro-B-type natriuretic peptide offers an additional tool for diagnostic assessment of patients presenting to the intensive care physician.
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Paul Collinson (2009) conducted an editorial in Cardiac dysfunction in critically ill patients. NTproBNP measurement was evaluated on Detection of cardiac dysfunction (AUC 0.76, 95% CI 0.69 to 0.83).
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