Key result
African-American race linked to ~56% higher post-AMI mortality, largely explained by eGFR differences.
Why the study?
Whether there are racial differences in the prevalence or prognostic importance of renal insufficiency in AMI is unknown.
Does decreased eGFR explain racial differences in survival among patients after acute myocardial infarction?
Cohort (n=1,847)
Yes
Does decreased eGFR explain racial differences in survival among patients after acute myocardial infarction?
Hazard Ratio: 1.56 (95% CI 1.2–2.1)
Renal insufficiency is a prognostically important comorbidity that partially explains the higher mortality observed in African Americans after acute myocardial infarction.
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eGFR adjustment attenuates racial mortality differences after AMI; leaves open whether kidney function mediates disparities in prospective studies.
Wetmore et al. (2011) conducted a cohort in Acute myocardial infarction (AMI) (n=1,847). African-American race vs. Other races was evaluated on 3.5-year all-cause mortality (HR 1.56, 95% CI 1.2-2.1). African-American race was associated with higher 3.5-year mortality after AMI (unadjusted HR 1.56; 95% CI 1.2-2.1), but this difference was substantially attenuated after adjusting for eGFR.
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