Key result
Smoking linked to ~65% higher hs-CRP, which correlates with insulin resistance.
Why the study?
The relationship between hs-CRP concentration and insulin resistance in smokers was unclear despite known elevated hs-CRP and CVD risk in smokers.
Cross-Sectional (n=121)
No
Effect estimate: 64.5% higher
Absolute Event Rate: 0.676% vs 0.411%
p-value: p=<0.0001
In male smokers with normal glucose tolerance, hs-CRP levels are significantly elevated and correlate with insulin resistance, suggesting that insulin resistance should be considered when evaluating hs-CRP in this population.
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Caution advised interpreting hs-CRP in male smokers without insulin resistance assessment; leaves open causal pathways and need for longitudinal studies.
Hanyu et al. (2009) conducted a cross-sectional in Healthy (Normal glucose tolerance) (n=121). Smoking vs. Nonsmokers was evaluated on High-sensitivity C-reactive protein (hs-CRP) concentration (64.5% higher, p=<0.0001). Smoking was associated with a 64.5% higher high-sensitivity C-reactive protein concentration compared to nonsmokers, and this inflammatory marker positively correlated with insulin resistance.
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