Key result
Active multiple sclerosis and HTLV-I-associated myelopathy linked to higher serum sICAM-1 levels versus controls.
Population
Patients with multiple sclerosis and human T-lymphotropic virus type I-associated myelopathy, and control…
Design
Case-control
Authors
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sICAM-1 elevation may signal inflammatory activity in MS and HAM; leaves open biomarker utility pending prospective validation.
Observational
p-value: p=<0.01
Serum sICAM-1 levels are elevated in active multiple sclerosis and HAM, suggesting its potential utility as a marker of inflammatory disease activity.
Tsukada et al. (1993) conducted an observational in Multiple sclerosis and human T-lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM). Multiple sclerosis and HAM vs. Control subjects was evaluated on Serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) (p=<0.01). Patients with active multiple sclerosis and HTLV-I-associated myelopathy had significantly higher serum levels of sICAM-1 compared to controls (p<0.01 and p<0.001, respectively).
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