Key result
CRRT for severe hand foot and mouth disease is linked to ~71% overall survival.
Why the study?
Mortality remains high in severe hand foot and mouth disease grade 4 indicated for continuous renal replacement therapy, prompting evaluation of earlier CRRT application to improve mortality.
Does continuous renal replacement therapy improve survival in patients with severe hand foot and mouth disease?
Observational (n=38)
No
Does continuous renal replacement therapy improve survival in patients with severe hand foot and mouth disease?
Continuous renal replacement therapy may improve survival in patients with severe hand foot and mouth disease, particularly when initiated early.
Background: The patients with severe hand foot and mouth disease (HFMD) grade 4 will be indicated continuous renal replacement therapy (CRRT), but the mortality rate is still high.The study was conducted to show the application of CRRT for severe HFMD patients in earlier stage improving the mortality.Method: A retrospective case series study was conducted about severe HFMD cases diagnosed clinically according to guidelines of the Ministry of Health and confirmed by Polymerase Chain Reaction (PCR) assay and having CRRT done.Variables would be recorded at admission, at starting CRRT and 16 hours later.The data were processed and analysed by software Stata version 14.0.Results: There were 38 eligible cases included in the study.The mean age was 25.3 months; the male: female ratio was 1.5.Most cases admitted within the first 3 day of illness (94.7%).The rate of HFMD grade 4 and grade 4 indicated CRRT was about 26.3% and 73.7% respectively.Vital signs, haematology parameters, biochemical parameters were improved significantly after 16 hours of CRRT.Average duration of CRRT was 2.4 ± 0.7 days.The survival rate of cases with HFMD grade 3 was 82.1% higher than that of cases with HFMD grade 4 at 40% significantly.Overall survival rate of HFMD patients indicated CRRT was about 71%. Conclusion:The CRRT could be considered as one of the measures that contributed to the improvement of mortality in patients with severe HFMD, and if the CRRT is indicated early it can produce much better results.
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Tuấn et al. (2019) conducted an observational in Severe hand foot and mouth disease (HFMD) (n=38). Continuous renal replacement therapy (CRRT) vs. HFMD Grade 4 (compared to Grade 3) was evaluated on Survival rate (Grade 3 vs Grade 4) (p=0.015). Continuous renal replacement therapy in patients with severe hand foot and mouth disease resulted in an overall survival rate of 71.0%, with significantly higher survival in grade 3 patients (82.1%) compared to grade 4 patients (40.0%).
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