Why the study?
Lack of compliance is a known problem in patients with hypertension, and the duration of blood pressure reduction by candesartan cilexetil needed clarification.
Does candesartan cilexetil maintain sustained blood pressure reduction in patients with hypertension?
Does candesartan cilexetil maintain sustained blood pressure reduction in patients with hypertension?
Answers are grounded in this paper and cite their sources.
Candesartan cilexetil provides sustained blood pressure reduction for up to 48 hours, which may be clinically beneficial for hypertensive patients with poor medication compliance.
Candesartan cilexetil is a highly potent and long-acting angiotensin II type I (AT1) receptor antagonist. This short review summarises results of clinical studies focusing on the duration of action of candesartan cilexetil. Results of previous clinical studies indicate that candesartan has the property to maintain a sustained blood pressure reduction for up to 48 h after dosing. Since lack of compliance is a known problem in patients with hypertension, these findings could be of particular clinical relevance.
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Bönner et al. (2005) conducted a review in hypertension. Candesartan cilexetil was evaluated on blood pressure reduction duration.
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