Prognostic implications of subclinical left ventricular dilatation and systolic dysfunction in men free of overt cardiovascular disease (the framingham heart study)
Key result
A 4% decrease in fractional shortening is linked to ~42% higher cardiovascular risk in men.
- RR 1.42
- 95% CI 1.12-1.81
- n=1,493
Why the study?
Does subclinical left ventricular dilatation and systolic dysfunction predict cardiovascular disease events in men free of overt cardiovascular disease?
Population
1,493 men free of symptomatic cardiovascular disease from the Framingham Heart Study
Design
Cohort
Follow-up
mean 4.15 years
Authors
Discussion
Loading...
Member takes
Implication
May inform risk stratification in asymptomatic men; leaves open whether screening alters management or outcomes.
Study Design
Type
Cohort (n=1,493)
Structured PICO
Does subclinical left ventricular dilatation and systolic dysfunction predict cardiovascular disease events in men free of overt cardiovascular disease?
P
Population
1,493 men free of symptomatic cardiovascular disease followed for a mean of 4.15 years.
E
Exposure
Presence of subclinical left ventricular dilatation (end-diastolic LV internal dimension ≥ 56 mm) and/or systolic dysfunction (fractional shortening ≤ 30%) assessed by M-mode echocardiography
O
Outcome
Cardiovascular disease eventscomposite
Main Result
Relative Risk: 1.42 (95% CI 1.12–1.81)
In men without overt cardiovascular disease, asymptomatic left ventricular dilatation and systolic dysfunction detected by echocardiography independently predict future cardiovascular events.
Cite This Study
Lauer et al. (1992) conducted a cohort in Free of symptomatic cardiovascular disease (n=1,493). Decrease of fractional shortening by 4% was evaluated on cardiovascular disease events (RR 1.42, 95% CI 1.12-1.81). A 4% decrease in fractional shortening was associated with an increased risk of cardiovascular disease events in men free of overt cardiovascular disease (RR 1.42; 95% CI 1.12-1.81).