What question did this study set out to answer?

To elucidate the maturation characteristics, trajectories, and health correlations of the infant gut microbiota using enterotype analysis and ecological modeling.

August 24, 2021Genome biologyOpen Access

Deterministic transition of enterotypes shapes the infant gut microbiome at an early age

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Authors

LXLiwen XiaoInstitute of Zoology JWJinfeng WangMinistry of Education JZJiayong ZhengWenzhou University

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Implication

Cohort analysis reveals predictable microbial enterotype transitions in infants across 17 countries, highlighting deterministic shifts toward adult-like gut communities.

Key Points

To elucidate the maturation characteristics, trajectories, and health correlations of the infant gut microbiota using enterotype analysis and ecological modeling.
Analyzed 13,776 fecal samples or datasets from 1,956 infants aged 1 to 3 years across multi-population cohorts spanning 17 countries.
Integrated clinical metadata from 2,287 records and applied ecological modeling and functional pathway analyses to determine developmental trajectories.
Infant microbiomes dominated by Firmicutes and Bifidobacterium displayed early developmental features, including low maturation and unstable community structure.
Microbiomes dominated by Bacteroides and Prevotella exhibited higher diversity, stronger ecological connectivity, and geography-related distribution patterns across global populations.
Ecological modeling showed a deterministic and predictable developmental transition where early Firmicutes and Bifidobacterium dominance is replaced over time by Bacteroides and Prevotella alongside adult-like metabolic pathway shifts.

Cite This Study

Xiao et al. (2021) studied this question.

synapsesocial.com/papers/6aa8f5ee9f1973992770f6c2 https://doi.org/10.1186/s13059-021-02463-3

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Implication

Cohort analysis reveals predictable microbial enterotype transitions in infants across 17 countries, highlighting deterministic shifts toward adult-like gut communities.

Deterministic transition of enterotypes shapes the infant gut microbiome at an early age

Discussion

Member takes

Implication

Key Points

Cite This Study

Deterministic transition of enterotypes shapes the infant gut microbiome at an early age

Discussion

Member takes

Implication

Key Points

Cite This Study

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