Key result
Family history, hypercholesterolemia, and current smoking are linked to large AAAs.
Why the study?
Are clinical risk factors and MMP9/MMP13 polymorphisms associated with large abdominal aortic aneurysms in Greek men?
Case-Control (n=341)
Are clinical risk factors and MMP9/MMP13 polymorphisms associated with large abdominal aortic aneurysms in Greek men?
p-value: p=<0.001
Family history, hypercholesterolemia, and smoking are significant risk factors for large abdominal aortic aneurysms in Greek men, whereas MMP9 and MMP13 polymorphisms are not independently associated.
Family history, hypercholesterolemia, and smoking were associated with large AAAs in Greek men; leaves open MMP13 variant contribution after correction.
Environmental and genetic risk factors contribute to the etiology of abdominal aortic aneurysms (AAAs). Matrix metalloproteinases (MMPs) have been associated with the pathophysiology of AAAs. A prospective, nonrandomized case-control study was undertaken to investigate the risk factors for large AAAs (≥5.5 cm) among 175 male Greek AAA patients and to compare the results with a cohort of 166 male controls free from any aortic dilatation, as confirmed by ultrasonography from an existing AAA screening program in the same region. We also assessed the potential association between 2 functional single nucleotide polymorphisms in the genes MMP9 (-1561C/T; rs3918242) and MMP13 (-77A/G; rs2252070), and the presence of large AAAs. Multiple logistic regression analysis revealed AAA family history ( P = .028), hypercholesterolemia ( P < .001), and current smoking ( P < .001) as AAA risk factors. Statistical difference was reached in genotype ( P = .047) and allele ( P = .037) frequencies for rs2252070, but the results did not remain significant after correction for multiple testing. No significant differences in genotype or allele frequencies for rs3918242 were detected. In summary, AAA family history, hypercholesterolemia, and current smoking were found to be risk factors for large AAAs.
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Makrygiannis et al. (2018) conducted a case-control in Large Abdominal Aortic Aneurysms (n=341). AAA family history, hypercholesterolemia, current smoking, and MMP polymorphisms vs. Controls free from aortic dilatation was evaluated on Presence of large AAAs (≥5.5 cm) (p=<0.001). AAA family history (P=0.028), hypercholesterolemia (P<0.001), and current smoking (P<0.001) were identified as significant risk factors for large abdominal aortic aneurysms in a Greek male cohort.
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