What question did this study set out to answer?

Synthesize current understanding of the complex biological, genetic, and epigenetic pathways governing pituitary neuroendocrine tumour development and progression.

June 28, 2022Frontiers in EndocrinologyOpen Access

Architects of Pituitary Tumour Growth

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Synthesize current understanding of the complex biological, genetic, and epigenetic pathways governing pituitary neuroendocrine tumour development and progression.
Narrative review evaluating cellular signalling pathways, histopathological markers, and tumorigenic routes in pituitary neuroendocrine tumours.
Synthesis of emerging concepts including cell death pathways, autophagy, stem cell involvement, cellular senescence, mitochondrial biology, and metabolic reprogramming.
Pituitary tumorigenesis relies on multiple interconnected signalling networks and cellular subpopulations rather than isolated defects in a single proliferative pathway.
Phenotypic diversity and clinical aggressiveness are shaped by emerging cellular processes, including metabolic reprogramming, altered mitochondrial activity, and senescence.
Integrating genomic, epigenomic, metabolic, and morphological data provides a more accurate framework for tumour classification, origin identification, and clinical prognosis.

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Implication

Review uncovers multifaceted molecular and cellular drivers of pituitary neuroendocrine tumours, highlighting the need for multi-omic classification schemes to improve prognosis.

Cite This Study

Sabatino et al. (2022) studied this question.

synapsesocial.com/papers/6aa8f6d7f031ab46a4d29c7c https://doi.org/10.3389/fendo.2022.924942

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Implication

Review uncovers multifaceted molecular and cellular drivers of pituitary neuroendocrine tumours, highlighting the need for multi-omic classification schemes to improve prognosis.

Architects of Pituitary Tumour Growth

Key Points

Discussion

Implication

Cite This Study

Architects of Pituitary Tumour Growth

Key Points

Discussion

Implication

Cite This Study

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