Key result
Eleven synthetic PAF derivatives show varying hypotensive activity despite identical vasodilation, indicating non-relaxation mechanisms.
Why the study?
The relationship between hypotensive activities of synthetic platelet activating factor derivatives and their endothelium-mediated vasodilation effects was unclear.
PAF-induced hypotension is not solely due to endothelium-related vascular relaxation observed in vitro.
Challenges endothelium-only model of PAF hypotension in animals; leaves open non-vascular mechanisms for future in vivo studies.
Hypotensive activities of 11 synthetic derivatives of platelet activating factor (PAF) were examined and compared with their activities to produce endothelium-related relaxation of isolated rat thoracic aorta. The derivatives showed variety of hypotensive activities; some of the derivatives were more potent than natural PAF and some were virtually inactive compared to PAF. However, all of the compounds tested exhibited exactly the same activities to produce endothelium-related vasodilation. These results confirmed our previous view that the PAF-induced hypotension is not solely due to the endothelium-related vascular relaxation observed in vitro.
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Shigenobu et al. (1985) studied this question. 11 synthetic derivatives of platelet activating factor (PAF) vs. natural PAF was evaluated on Hypotensive activities and endothelium-related relaxation. Eleven synthetic derivatives of platelet activating factor showed varying hypotensive activities but identical endothelium-related vasodilation, indicating hypotension is not solely due to vascular relaxation.
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