Key result
Relaxation of pre-contracted rat thoracic aorta strips by platelet activating factor and acetylcholine required the presence of endothelial cells.
Why the study?
Does the endothelium mediate the vasodilator response of rat thoracic aorta to platelet activating factor?
Does the endothelium mediate the vasodilator response of rat thoracic aorta to platelet activating factor?
The study demonstrates that the vasodilating effect of platelet activating factor in rat thoracic aorta is endothelium-dependent.
PAF-induced relaxation requires intact endothelium in rat aorta; leaves open translation to human vessels or in vivo effects.
As the endothelium has an important role in the vasodilating effect of acetylcholine, we investigated the possible role of the endothelium in the vasodilating effect of platelet activating factor (PAF). Experiments were done on spirally cut rat thoracic aorta either containing or denuded of endothelial cells. It was demonstrated that relaxation by PAF and acetylcholine of pre-contracted strips required the presence of endothelial cells. The results strongly suggested the possible involvement of endothelium in the vasodilation produced by PAF as well as by ACh.
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Kasuya et al. (1984) studied this question. Platelet activating factor (PAF) vs. Aorta denuded of endothelial cells was evaluated on Vasodilation / relaxation of pre-contracted strips. Relaxation of pre-contracted rat thoracic aorta strips by platelet activating factor and acetylcholine required the presence of endothelial cells.
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