August 1, 1994British Journal of PharmacologyOpen Access

Role of R‐type calcium channels in the response of the perfused arterial and venous mesenteric vasculature of the rat to platelet‐activating factor

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Population

Rat double-perfused mesenteric bed

Design

Preclinical

Authors

ACAudrey ClaingUniversité de Montréal GBGhassan BkailyUniversité de Sherbrooke NBNathalie BerthiaumeHoward Hughes Medical Institute

Discussion

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Implication

Supports R-type channel role in PAF mesenteric responses in rats; leaves open any human therapeutic relevance.

Structured PICO

Population

Rat double-perfused mesenteric bed

Intervention

Platelet-activating factor (PAF) (0.01-0.3 pmol) and various antagonists/inhibitors (L-NAME, WEB-2170, SRI-63441, isradipine, nifedipine)

Outcome

Vasoactive responses (vasodilatation and vasoconstriction) in the arterial and venous mesenteric vasculaturesurrogate

PAF induces differential vasoactive responses in the rat mesenteric vasculature that appear to be mediated through activation of specific receptors or R-type calcium channels.

Cite This Study

Claing et al. (1994) studied this question.

synapsesocial.com/papers/6a83fc3120cfb2932ffe3081 https://doi.org/10.1111/j.1476-5381.1994.tb13211.x

View Full Paper

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Role of R‐type calcium channels in the response of the perfused arterial and venous mesenteric vasculature of the rat to platelet‐activating factor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of R‐type calcium channels in the response of the perfused arterial and venous mesenteric vasculature of the rat to platelet‐activating factor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider