January 1, 2002British Journal of PharmacologyOpen Access

Comparison of the contractile and calcium‐increasing properties of platelet‐activating factor and endothelin‐1 in the rat mesenteric artery and vein

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Population

Rat mesenteric arteries and veins

Design

Preclinical

Authors

ACAudrey ClaingUniversité de Montréal HSHadia ShbakloUniversité de Sherbrooke MPMirco PlanteUniversité de Sherbrooke

Discussion

Member takes

Implication

Animal data on mesenteric reactivity remain preliminary; leaves open whether PAF or ET(B) pathways offer venous-selective targets in humans.

Structured PICO

Population

Rat mesenteric arteries and veins

Intervention

Platelet-activating factor (PAF) and endothelin-1 (ET-1), along with various ET receptor agonists (IRL-1620, sarafotoxin S6C) and antagonists (BQ-123, BQ-788, SB 209670)

Outcome

Vessel contraction (tension) and intracellular-free calcium levels (cytosolic and nuclear)surrogate

PAF and ET-1 exert distinct, receptor-specific contractile and calcium-mobilizing effects on rat mesenteric veins compared to arteries.

Cite This Study

Claing et al. (2002) studied this question.

synapsesocial.com/papers/6a83fc71b5a613d8fb3e9f70 https://doi.org/10.1038/sj.bjp.0704441

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Implication

Animal data on mesenteric reactivity remain preliminary; leaves open whether PAF or ET(B) pathways offer venous-selective targets in humans.

Comparison of the contractile and calcium‐increasing properties of platelet‐activating factor and endothelin‐1 in the rat mesenteric artery and vein

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Comparison of the contractile and calcium‐increasing properties of platelet‐activating factor and endothelin‐1 in the rat mesenteric artery and vein

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider