Key result
The minor allele of CRP SNP 2667G>C was associated with lower plasma CRP levels but an increased risk of incident coronary heart disease in both women (OR 1.57) and men (OR 1.93).
Why the study?
Do CRP gene polymorphisms predict the risk of incident coronary heart disease in adults?
Case-Control (n=1,544)
Do CRP gene polymorphisms predict the risk of incident coronary heart disease in adults?
Answers are grounded in this paper and cite their sources.
Genetic variations in the CRP gene affect plasma CRP levels but do not predictably correspond to changes in CHD risk, suggesting CRP may not be a direct causal factor for coronary events.
BACKGROUND: C-reactive protein (CRP), an acute phase reactant and marker of inflammation, has been shown to predict risk of incident cardiovascular events. However, few studies have comprehensively examined six common single-nucleotide polymorphisms (SNPs) in the CRP gene, haplotypes, and plasma CRP levels with risk of coronary heart disease (CHD). METHODS AND FINDINGS: We conducted parallel nested case-control studies within two ongoing, prospective cohort studies of U.S. women (Nurses' Health Study) and men (Health Professionals Follow-up Study). Blood samples were available in a subset of 32,826 women and 18,225 men for biomarker and DNA analyses. During 8 and 6 years of follow-up, 249 women and 266 men developed incident nonfatal myocardial infarction or fatal CHD, and controls (498 women, 531 men) were matched 2:1 on age, smoking, and date of blood draw from participants free of cardiovascular disease at the time the case was diagnosed. Among both women and men, minor alleles were significantly associated with higher CRP levels for SNPs 1919A>T and 4741G>C, but associated with lower CRP levels for SNPs 2667G>C and 3872C>T. SNP 2667G>C was individually associated with increased risk of CHD in both women [OR 1.57 (95% CI 1.01-2.44); p = 0.047] and men [1.93 (95% CI 1.30-2.88); p = 0.001]. Two of the five common haplotypes were associated with lower CRP levels, and Haplotype 4 which included minor alleles for 2667 and 3872 was associated with significantly lower CRP levels and an elevated risk of CHD. The remaining SNPs or haplotypes were not associated with CHD in both populations. CONCLUSIONS: Common variation in the CRP gene was significantly associated with plasma CRP levels; however, the association between common SNPs and CRP levels did not correspond to a predicted change in CHD risk. The underlying inflammatory processes which predict coronary events cannot be captured solely by variation in the CRP gene.
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Pai et al. (2008) conducted a case-control in Incident coronary heart disease (n=1,544). CRP gene polymorphism 2667G>C vs. Major allele (2667G) was evaluated on Incident nonfatal myocardial infarction or fatal coronary heart disease (OR 1.57, 95% CI 1.01-2.44, p=0.047). The minor allele of CRP SNP 2667G>C was associated with lower plasma CRP levels but an increased risk of incident coronary heart disease in both women (OR 1.57) and men (OR 1.93).
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