Why the study?
Do common CRP gene variants associate with baseline CRP levels and the risk of incident myocardial infarction or ischemic stroke in apparently healthy subjects?
Population
Apparently healthy subjects from the Women's Health Study, Pravastatin Inflammation/CRP Evaluation trial…
Comparison
Common CRP gene single nucleotide polymorphism… vs Alternative alleles/wild-type
Design
Case-control
Authors
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CRP variants do not link higher levels to MI or stroke risk; leaves open CRP as marker rather than causal factor.
Do common CRP gene variants associate with baseline CRP levels and the risk of incident myocardial infarction or ischemic stroke in apparently healthy subjects?
Genetic variants that increase CRP levels are not associated with an increased risk of incident MI or ischemic stroke, suggesting CRP may be a risk marker rather than a direct causal factor for atherothrombotic events.
Miller et al. (2005) studied this question.
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