Key result
ABPM standing tests detect orthostatic hypotension with ~82% sensitivity using standard SBP drop criteria.
Why the study?
Does 24-hour ambulatory blood pressure monitoring with standing tests accurately diagnose orthostatic hypotension compared to head-up tilting in patients with Parkinson's disease and multiple system atrophy?
Cross-Sectional (n=74)
No
Does 24-hour ambulatory blood pressure monitoring with standing tests accurately diagnose orthostatic hypotension compared to head-up tilting in patients with Parkinson's disease and multiple system atrophy?
Effect estimate: AUC 0.91 (95% CI 0.84-0.98)
24-hour ambulatory blood pressure monitoring with a standing test is highly specific and sensitive for diagnosing orthostatic hypotension in patients with Parkinson's disease and multiple system atrophy, offering a practical alternative to head-up tilt testing.
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24-h ABPM standing test may aid OH detection in PD/MSA; leaves open routine adoption pending prospective validation.
Vichayanrat et al. (2016) conducted a cross-sectional in Parkinson's disease and Multiple System Atrophy (n=74). 24-hour ambulatory blood pressure monitoring (24hr-ABPM) standing test vs. Head-up Tilting (HUT) was evaluated on Sensitivity and specificity of SBP fall >20 mmHg during 24hr-ABPM standing test for detecting orthostatic hypotension (AUC 0.91, 95% CI 0.84-0.98). A systolic blood pressure fall of >20 mmHg during a standing test using 24-hour ambulatory blood pressure monitoring demonstrated 82% sensitivity and 100% specificity (AUC 0.91) for detecting orthostatic hypotension.
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