Key result
CO2-induced acidosis reduces isometric tension-time integral by ~50% versus normocapnia at low pacing frequencies.
Population
Anesthetized rabbits (gastrocnemius and soleus muscle groups)
Comparison
CO2-induced acidosis and submaximal sciatic… vs Normocapnia
Design
Preclinical
Authors
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Acidosis halves rabbit cardiac muscle work without altering oxidative enzyme kinetics; leaves open relevance to human myocardial energetics.
In a rabbit model, CO2-induced acidosis reduced muscle performance (TTI) but did not alter the Michaelis-Menten constant (Km) or maximal reaction velocity of oxidative phosphorylative enzymes.
Nioka et al. (1992) studied CO2-induced acidosis and muscle fatigue. CO2-induced acidosis vs. Normocapnia was evaluated on Intracellular pH and isometric tension-time integral (TTI). CO2-induced acidosis reduced intracellular pH from 6.9 to 6.7 and reduced the isometric tension-time integral to below half the value measured in normocapnia at low pacing frequency.
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