Key result
Prostaglandin availability drives membrane order changes necessary for bilayer fusion during in vitro myogenesis.
Why the study?
The role of prostaglandin binding in the membrane order changes that accompany myoblast adhesion and fusion during in vitro myogenic differentiation was unclear.
Population
Myoblasts in vitro
Comparison
Indomethacin-treated myoblasts vs exogenous prostaglandin-treated myoblasts
Design
Preclinical in vitro study
Authors
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No immediate clinical implications for muscle regeneration; leaves open in vivo and cardiac translation of prostaglandin-dependent membrane changes.
Prostaglandin binding is required for the membrane order changes that precede cell-cell adhesion and bilayer fusion during in vitro myogenesis.
Santini et al. (1988) studied Myogenic differentiation in vitro. Prostaglandin vs. Indomethacin (prostaglandin synthesis inhibitor) was evaluated on Membrane order change during myogenesis. Membrane order changes during in vitro myogenesis, which prepare the membrane for bilayer fusion and increase adhesion, are dependent on the availability of prostaglandin.
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